Funnily enough, the most "fuck you" tree is actually from America:

Standing beneath the tree during rain will cause blistering of the skin from mere contact with this liquid: even a small drop of rain with the sap in it will cause the skin to blister. Burning the tree may cause ocular injuries if the smoke reaches the eyes.

Although the fruit is potentially fatal if eaten, no such occurrences have been reported in the modern literature. Ingestion can produce severe gastroenteritis with bleeding, shock, and bacterial superinfection, as well as the potential for airway compromise due to edema.