The 64GB Framework Desktop runs just barely over 2k configured minimally, I went that route because I thought it was a better option than the discrete 32GB video card, but there are tradeoffs with compatibility. Something to think about at the 2k, but not quite 3k range though.
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With older hardware, once you accumulate enough vram to run it, your problem is going to shift to memory bandwidth and your question is going to shift from 'Can I run this Model' to 'Can I run this Model at an acceptable speed'.