empty/depleted fat cells basically scream “we are hungry”, so as soon as you get off Ozempic, you basically can’t stop eating until you regained at least the former state.
I don't think that is quite right. If people on Ozempic use the opportunity to adapt to a low carbohydrate diet, when they come off the drugs they won't be suffering from the save sugar craving addiction cycle.
Fat cells don't scream "we are hungry" they scream "we are full" that is what leptin signaling is for, but carbohydrate addiction is a much stronger signal for many people.
In my reading the the literature there is nothing to support this "fat cells make you hungry" theory.
At best there is an association between fat people and fat cell population, but given hyperplasia is more common in people of european descent its not a causal connection. Plus this theory doesn't account for fat people from hypertrophic populations (asians).