If you're wanting a planned in advance ideal solution, that's not really possible, but people can collectively respond to problems as they happen and adapt, as long as they aren't constrained from doing so.

I believe the pattern and tactics you describe are always going to be more effective on a platform controlled by a company like Reddit, because any efforts to counter them are ultimately limited by the agenda of the platform owners. There are people on Reddit trying to investigate and call out deceptive commercial spam, but when the spammers block them to prevent a response, set their post history to be unreadable, buy moderator positions, and admins only care about their own power and profitability (cutting users off from api etc), the deck is stacked against them. In the end it's just not their website.

Ultimately this is an organizational challenge, not only a technical or platform design challenge. If the organization is a collection of users who generally want genuine non-manipulative interaction between real people, and the protocol is set up to make it easy for them to route around malicious attempts to usurp control, that doesn't mean immediate victory over adversaries but it is a big leg up.