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SoleInvictus

@ SoleInvictus @lemmy.blahaj.zone

Posts
2
Comments
541
Joined
2 yr. ago

  • TIL that cancer drug Revlimid is one of the bestselling products of all time. It cost nearly $1,000 per pill, even though that same pill cost just 25 cents to make

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  • The price of biologics kills me. I know it costs about $20 dollars for a month of GLP-1 agonists, because I've made similar peptides myself in grad school. Something like a Solid Phase Peptide Synthesizer runs $10-250K, but the cost to synthesize a 40 amino acid linear peptide at industrial scale is like...$0.30 USD per milligram. Shorter chain peptides are even cheaper. A 15AA linear peptide can be as low as $0.01/mg.

    There are of course other expenses, especially labor, facilities, certification, and waste disposal, but these companies are still easily making 40-50% profit margins on biologics. Compare this to non-biologics pharmaceutical profit margins around 15-25%, or for other industry comparisons, grocery stores around 1-3%, restaurants 3-10%, and software at 15-20%.

  • Man jailed for a month despite Flock showing he was 5 miles from crime scene

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  • I still remember the rage I felt when I first realized that the United States justice system is fundamentally adversarial. Prosecuting attorneys don't want to find the truth of the matter. The build the strongest case possible and it's on the defendant to prove they're wrong. Attorneys are supposed to take into account all available evidence, but have no obligation to seek additional information that could exonerate the defendant, even if it's clear such information exists.

    It's absolutely fucked.

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  • It's a CT (computerized tomography) scan. It still uses X-rays but the results are in 3D so one can view "slices" of the image from different perspectives.

    The sternum is in the the same plane as the spine from this angle, so that's why there's only the slightest hint of a ribcage and only the sternum - this slice is well past rib bones.

    Similarly the shoulder is much closer to the viewer's perspective in the 3d model, so it's not shown at all.

    Edit: misinterpreted CT slice location.

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  • Great explanation, well done!

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  • Doing this in the theater was awesome, but it was difficult getting a responsible sober person to shepherd a group of people tripping balls safely there and back. That's a much harder job than many people realize.

  • All Hail Gamblor [PizzaCake]

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  • I've been gambling before and it was fun when I won money. The thing is I know how, with few exceptions with games like poker and blackjack (and only then if you're skilled), you will ALWAYS lose more money than you win over long enough of a time period.

    I'm a big, walking math machine, though, so I've been the person getting a little too tipsy at the roulette table and telling everyone exactly how probability works and that numbers are never "hot". The roulette dealer was surprisingly amused.

  • Go ahead and reward yourself with a very small cookie, or maybe a string cheese.

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  • Yep, it's all cumulative. I think the "weight loss is in the kitchen" advice helps those who don't understand weight loss is a function of net calories, so start exercising and eat more because they think exercise somehow magically makes weight go away. If only I had a nickel for every time I heard "weight lifting converts fat into muscle" over the years...

    My aunt is a great example. She started doing daily walks to lose weight but picked up a "healthy protein smoothie" from a local coffee shop on the way home. She slowly gained weight because they were more like milkshakes and easily had 500+ calories per serving.

  • Plex increasing Lifetime Plex Pass cost to whopping $750

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  • There is at least one TV application that doesn't support local streaming without first logging into Plex's servers. I have an LG tv and it'll hang at the loading screen, then error out if I don't have Internet connectivity. I love the TV but LG as a company sucks. I wouldn't buy it again.

  • Schiff Proposes Bill Requiring Data Centers to Pay for Own Power

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  • Given we have the technology, any new construction should be required to be environmentally neutral at a minimum, ideally with ongoing improvement.

    If they need to use millions of gallons of groundwater? Great, go fucking wild, but directly fund managed aquifer recharge projects to replace that groundwater at an equal or greater rate.

    Increases in resource consumption should be covered entirely by the data center plus improvements to benefit the community.

    No longer should big business be used as a means to siphon the value of labor and natural resources and concentrate it for selfish use by the worst of humanity.

  • Plex’s price hikes prove I was right to switch to Jellyfin

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  • 100% right on for me. It took me years, YEARS, to get my mother to where she would check if USB peripherals were plugged in before asking me to come over and find out why it was broken. Even the occasional slight complications with Plex get her to where she doesn't use it for months unless I fix it for her. Jellyfin just ain't happening with her.

  • Pastor leads leads wild dedication ceremony for Trump’s giant gold statue

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  • I thought that was a golden calf, not a jackass.

  • You choose where you go in the Federation

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  • Barclay is down to play too.

  • AOC's answer on running for president leaves political world speechless

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  • Plus the article itself is primarily dramatic fluff writing, followed by something I loathe: quotations from social media reactions. I'd love for anyone that does like them to share why because I cannot see the utility.

  • Trump’s disapproval rating hits record high, new poll shows

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  • They're not the brightest, which we all know tends to correlate strongly with conservatism. I'll always remember the idiots in 2004 who voted for a second W. Bush term because "he made this mess, now he needs to clean it up".

    That's like hiring an incompetent employee who messed up a mission-critical project and not only took no accountability, but verifiably lied about their actions, yet you continue employing them to finish the project.

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  • You wanna take some time to gather your thoughts first?

    Either you're quite condescending or there is some confusion here. I'm going to assume it's the latter; if it's the former, well... life is an adventure.

    Yeah but, which part exactly should I not understand because of my American education?

    I'm not referring to you in my original comment[1](https://lemmy.blahaj.zone/comment/20221397), but to the person to whose comment I'm responding.

    So you’re not talking about Marx and Engels, but you are somehow talking about socialism AND scientific socialism no less?

    The vocabulary I said I wasn't referring to is the list of terms provided by Prole[2](https://lemmy.blahaj.zone/comment/20225314) in response to your question[3](https://lemmy.blahaj.zone/comment/20225057). My original comment was offhand, not intended to be a detailed analysis, so their response was assumptive. I'm familiar with the user and they're good people, so I'm sure it was in good faith.

    To answer your original question, here are specific terms in the Wikipedia article[4](https://en.wikipedia.org/wiki/Scientific_socialism) I would suggest are not covered in US public education with sufficient depth or frequency to give the average citizen the functional vocabulary necessary to fully understand the article without significant further reading. I.e., most Americans would be unable to provide even a basic (correct) definition if asked.

    MaterialismHistorical materialismDialectical materialismUtopian socialismScientific government/Technocracy(though briefly described in line)Classical liberalismMarxism

    And by extension...

    Scientific socialism

    The United States ranks 36th in the world for population literacy, with 54% of Americans reading below a 6th-grade proficiency level and 21% being functionally illiterate[5](https://www.thenationalliteracyinstitute.com/2024-2025-literacy-statistics), so I'm pretty comfortable with my suggestion but am willing to be convinced otherwise.

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  • If you're from the US, much of the vocabulary is unfamiliar because education on these concepts is intentionally avoided in public schools. I can't imagine why...

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  • It's actually used a lot in food, along with other agricultural waste materials. You'll find it listed in ingredients as cellulose. It's processed to hell and indigestible, so it doesn't really do much nutritionally beyond adding a bit of dietary fiber.

  • Electricity explained

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  • I truly am terrible: terribly educational!

    /Dad joke

  • Electricity explained

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  • I absolutely love the the hydraulic analogy, and my advancing age and the 'tism compels me to share a story.

    I was a science major and worked as a tutor through college. Intermediate physics was required for all science degrees, so basic electrical theory consistently came up.

    What I love about the analogy is it's actually not perfectly analogous, but the differences become obvious once the initial concepts are understood, then those differences help students figure it all out. Its imperfection is actually what makes it perfect, and my nerdy side just loves that kind of stuff.

    The students that argued with me the most about how it was a shit analogy were my favorite because they'd so frequently knock it out of the park come exam time. It was like the academic equivalent of hate fucking.