However you want to do it. Keep in mind that the vent positions are there for a reason (unless it's a shitty case). Proper airflow should be a priority. This does not mean, "open hole = more flow"
When SpongeBob says, "Patrick, your genius is showing!" and Patrick says, "what!? Where?!" and covers his crotch. If you weren't listening, it really does sound like, "Patrick, your penis is showing." and it caught me off guard the first time.