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InverseParallax

@ InverseParallax @lemmy.world

Posts
3
Comments
719
Joined
3 yr. ago

  • Terry Farrell shares a DS9 memory

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  • More often they've already had sex with them, so they don't matter anymore.

  • The Doctor only wishes

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  • The Doctor only wishes

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  • Damn you, now I have to start a pertwee rewatch!

  • Terry Farrell shares a DS9 memory

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  • I will NEVER understand slut shaming.

    "Women willing to have sex? Fuck, we gotta humiliate them and discourage that!

    Not on my watch... "

  • Terry Farrell shares a DS9 memory

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  • pew pew space battles and ignore the messaging.

    Hey, we don't have to get personal here :(

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  • The money people are demanding much higher returns, inflation spooked them, but the fact that it's going down is no reason to not keep squeezing.

  • TSA silent on CrowdStrike’s claim Delta skipped required security update

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  • I am less certain about Microsoft, though I think they need to have their ass handed to them for their high-handed treatment of push patches.

    Either they need to implement staggered deployment by default, or they need to get out of the update deployment business altogether if they don't want the liability, can't have it both ways.

    We know this didn't happen, because CS.

  • YouTube tests removing viewer counts — here’s what we know

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  • Gemini Ai makes up a title for you.

    That's as cursed as I can make it.

  • The Magic Keyboard, Trackpad and Mouse now use USB-C!

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  • TSA silent on CrowdStrike’s claim Delta skipped required security update

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  • Imagine being responsible for forcing a security update on your customers without testing it.

    Negligence absolutely applies here, Crowdstrike needs to be sued out of existence.

  • For four hours, Christians in Georgia gathered to worship Trump. I was there.

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  • E's not the messiah! E's a very naughty boy!

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  • Yeah, I didn't do the carbonic acid, then there's the increased bicarb buffering around the pleura, couple other facts.

    https://www.ncbi.nlm.nih.gov/books/NBK539815/

    Upon entrance into red blood cells, carbon dioxide is quickly converted to carbonic acid by the enzyme carbonic anhydrase. Carbonic acid immediately dissociates into bicarbonate and hydrogen ions. As previously stated, an increase in hydrogen ions stabilize the hemoglobin in the T-state and induces oxygen unloading which leads to shifting of the dissociation curve to the right.[6]

    Thus the acidity causes o2 release. Temperature (lungs tend to be very cold in the body) is important too.

    Oxygen unloading is favored at higher temperatures which will cause a rightward shift. On the other hand, lower temperatures will cause a leftward shift in the dissociation curve. A notable example of this is exercise, where the temperature of muscle increases secondary to its utilization, thus shifting the curve to the right and allowing oxygen to be more easily unloaded from hemoglobin and deliver to tissues in need.

    It's amazing how subtly it works to gently increase efficiency where we need it. Otherwise it's just a very weak oxygen bond (which is hard enough given oxygen is extremely non-polar and all you have are the valence pairs. edit: This lead me to wonder how the fuck it even bonded effectively

    https://www.jbc.org/article/S0021-9258(19)63845-7/fulltext

    Wow, I'm impressed, they're using spin-coupling which is a pretty dicey effect.

    Thus, we can conclude that the facile binding of O2 to hemo- and myoglobin arises primarily as an effect of the topology of the binding curves for the four relevant spin states. This topology, with nearly degenerat>e and parallel curves, is caused by the near degeneracy (within 10 kJ/mol) of the triplet and quintet states of deoxyheme. Therefore, the design by nature of iron porphines having close-lying spin states of a particular symmetry and energy is a means to tune binding of small ligands and overcome the activation barriers of these spin-forbidden reactions, despite the moderate SOC of first-row transition metals. The resulting barrier height makes up most of the rate enhancement due to the exponential dependence on the rate, whereas one or two orders of magnitude may come from the increase in the transmission coefficient.

    That's some fucking crazy ass engineering by nature, A weak, highly reversible bond with the molecule keyed to both pH and thermal triggers. That was a fun rabbit hole.

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    1. It's sensitive to pH, so it absorbs oxygen more readily in the lungs, and releases it slightly more near tissues that need it, as they have co2 which slightly acidifies the blood in solution (h2co3).
    2. It's effective and well tuned for our biology, it doesn't bond strongly, and is well suited for the air-blood interface, unlike others that often favor water-blood or water-the fluid worms use instead.

  • If you're in the US, how are you preparing for the election and dealing with the stress?

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  • Around 2008, basically all the Texans who screwed up US politics saw their gravy train ending and ran north to exploit Alberta's new oil.

    I'm sorry, but it's like apologizing for locusts.

  • The Magic Keyboard, Trackpad and Mouse now use USB-C!

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  • Jesus, there are easier ways, just have the whole mouse be electrified to lethal levels when plugged in, it still wouldn't look as bad.

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  • Their version of pre-natal vitamins.

  • Microsoft accuses Google of secretly funding regulatory astroturf campaign

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  • I... I mean wow.

    There's an old legal term which apples here, I believe it's a Latin loan phrase: "You've got some fucking chutzpah!"

  • What smartphone do your use? What's the best phone you had owned?

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  • Had the fold 3, was fine at first, but my eyes aren't as perfect, and the screen was so thin it was less usable folded.

    The pixel fold has a better form factor, but it crappier otherwise.

  • If you're in the US, how are you preparing for the election and dealing with the stress?

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  • We survived one term, this one will be worse, but if we stop being idiots and let them distract us with 1000 tiny controversies then we can solve anything.

    He had nearly unlimited power last time and we did OK, though McCain helped and that corporate tax cut was brutal.

    I think America has become politically lazy, sometimes you have to take a stand for your principles, and we've gotten used to expecting the idiots on TV to do that for us.

    If he 'wins' and we put 10m people on Pennsylvania Avenue, I think we can make it clear that he serves us, not the other way around.

    But we won't do that, we'll expect everyone else to instead...