Bad guys who aren't misunderstood but aren't bad. They occupy a niche mindspace in which they have a genuine and noble goal but their goal is mutually exclusive with the good guy's goals (the Shadowlord from Nier Gestalt)
Then, on the flip side, bad guys who know that they're bad and revel in it (Jack Horner from Puss in Boots)
Good guys who are good leaders. They have no superhuman abilities but their power is to bring out the best in others. They don't beat the bad guys through sheer strength or being inspired by the power of friendship (which IMO is just the same thing), but they do so by strategically playing to people's strengths (Senku from Dr. Stone)
It should also be mentioned that the two methods aren't mutually exclusive, and there's a ton of synergy between using the old ways (x-ray crystallography and cryo-em) and using the new way (AlphaFold). Because even when you measure the protein structure, the old ways only tell you the shape of the protein but not the skeletal structure of the protein (which is the actual important part), so to my knowledge, there's a bit of finicking around to figure out how the protein folds into that shape. AlphaFold predicts how the protein folds, so you can cross reference that with the measured shape of the protein to better estimate where the protein skeleton is in the measured shape